1998 Jeep Grand Cherokee started sputtering when I reached about 45 mph it started sputtering.?

1998 Jeep Grand Cherokee started sputtering when I reached about 45 mph it started sputtering.The gas gauge would fall to empty,the check engine light would come on and it felt like it wanted to stall.All plugs are good and vacuum lines connected correctly,air filter is new.Any suggestion's to what can be the problem?